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Summary of TKTL1 suppression

  • Lower glucose consumption and lactate production after TKTL1 suppression
  • Reduction of HIF-1 alpha and phosphorylated Akt after TKTL1 suppression
  • Reduced cell proliferation after TKTL1 suppression
  • Increased ROS concentration after TKTL1 suppression
  • Increased cell mobility and invasiveness after TKTL1 overexpression
  • TKTL1 suppression leads to reduced tumour growth in a xenograft model