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Literature

Publications TKTL1 sorted by subject areas

Endocrinology

Thyroid cancer:

Zerilli M et al: Increased expression of transketolase-like-1 in papillary thyroid carcinomas smaller than 1.5 cm in diameter is associated with lymph-node metastases. Cancer. 2008 Sep 1;113(5):936-44. University of Palermo, Palermo, Italy

Gastroenterology

Colorectal cancer:

Bentz S et al: Hypoxia induces the expression of transketolase-like 1 in human colorectal cancer.
Digestion. 2013;88(3):182-92. Universitätsspital Zürich

Jansen N und Coy JF: Diagnostic use of EDIM-blood test for early detection of colon cancer metastasis. Future Oncol. 2013;9(4):605–9

Schwaab J et al: Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy. BMC Cancer 2011;11:363. University of Medicine Mannheim, Mannheim, Germany

Diaz-Moralli S et al: Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One. 2011;6(9):e25323. Epub 2011 Sep 27

Xu X et al: Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer. 2009 Mar 15;124(6):1330-7. DKFZ Heidelberg, Germany

Langbein S et al: Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer. 2006 Feb 27;94(4):578-85. University of Medicine Mannheim, Mannheim, Germany

Gastric cancer:

Yuan W et al: Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivo. Cancer Biol Ther. 2010 May;9(9):710-6. Epub 2010 May. Central South University, Changsha, Hunan, China

Staiger WI et al: Expression of the mutated transketolase TKTL1, a molecular marker in gastric cancer. Oncol Rep. 2006 Oct;16(4):657-61. University Hospital Mannheim, Mannheim, Germany

Gynaecology

Breast cancer:

Rotmann et al: A new diagnostic approach for the early detection and monitoring of breast cancer patients. 9th European Breast Cancer Conference (EBSS-9)

Rotmann A et al: A new diagnostic test for monitoring of breast cancer patients. Abstract German cancer congress 2014

Grimm M et al: A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer 2013, 13:569. University Hospital Tuebingen, DKFZ Heidelberg

Rotmann A: The use of new diagnostic tests for the monitoring of new and existing therapies for breast cancer patients. Journal of Clinical Oncology, ASCO Meeting Abstracts. 2013; 31:e22006

Feyen O et al: EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. 2012;8(10):1349-59. Rhönklinikum Bad Berka, Bad Berka, Germany

Feyen O et al: EDIM blood test: a non-invasive method to detect patients with malignancies. Cell Symposia July 6-8, 2012: Poster

Rotmann A et al: Apo10 - a new biomarker for early detection of disorders of cell proliferation and solid tumours. Int J Gynaecol Obstet 119, Supplement 3 (2012), S466. Abstract Figo 2012

Schmidt M et al: Glycolytic phenotype in breast cancer: activation of Akt, up-regulation of GLUT1, TKTL1 and down-regulation of M2PK. J Cancer Res Clin Oncol. 2010 Feb;136(2):219-25. Epub 2009 Aug 5. University Hospital Würzburg, Würzburg, Germany

Rotmann A et al: TKTL1 - a new biomarker and its relevance in the daily gynaecological practice. Poster FIGO 2009

Földi M et al: Transketolase protein TKTL1 overexpression: A potential biomarker and therapeutic target in breast cancer. Oncol Rep. 2007 Apr;17(4):841-5. University Hospital Freiburg, Freiburg, Germany

Endometrial cancer:

Krockenberger M et al: Expression of transketolase-like 1 protein (TKTL1) in human endometrial cancer. Anticancer Res. 2010 May;30(5):1653-9. University of Wuerzburg, Wuerzburg, Germany

Ovarian cancer:

Schmidt M et al: Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. Eur J Obstet Gynecol Reprod Biol. 2008 Jul;139(1):72-8. Epub 2008 Apr 3.
University of Wuerzburg, Wuerzburg, Germany

Krockenberger M et al: Transketolase-like 1 expression correlates with subtypes of ovarian cancer and the presence of distant metastases. Int J Gynecol Cancer 2007 Jan-Feb;17(1):101-6. University of Wuerzburg, Wuerzburg, Germany

Cervix cancer:

Chen H et al: Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer. J Exp Clin Cancer Res. 2009 Mar 30;28:43. Huazhong University of Science & Technology, Wuhan, Hubei, China

Kohrenhagen N et al: Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia. J Obstet Gynaecol Res. 2008 Jun;34(3):293-300. University of Wuerzburg, Wuerzburg, Germany

Neurology

Brain cancer:

Wanka C et al: Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvationinduced cell death by upregulating respiration and improving cellular redox homeostasis. J Biol Chem. 2012 Sep 28;287(40):33436-46. Epub 2012 Aug 10

Wani K et al: A prognostic gene expression signature in infratentorial ependymoma. For the Collaborative Ependymoma Research Network. Acta Neuropathol. 2012 May;123(5):727-38. Epub 2012 Feb 10. The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA

Völker HU et al: Expression of transketolase-like 1 and activation of Akt in grade IV glioblastomas compared with grades II and III astrocytic gliomas. Am J Clin Pathol. 2008 Jul;130(1):50-7. University of Wuerzburg, Wuerzburg, Germany

Ophthalmology

Lange CA et al: Enhanced TKTL1 Expression in Malignant Tumors of the Ocular Adnexa Predicts Clinical Outcome. Ophthalmology. 2012 Jun 1. Epub ahead of print. University Hospital Freiburg, Freiburg, Germany

Otolaryngology

Head and neck cancer:

Grimm M et al: A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 2013, 13:569. University Hospital Tuebingen, DKFZ Heidelberg

Grimm M et al: Transketolase-like protein 1 expression in recurrent oral squamous cell carcinoma after curative resection: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Jul 20. Epub ahead of print. University Hospital Tübingen, Germany

Hartmannsberger D et al: Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. Cancer Lett. 2011 Jan 1;300(1):20-9. Epub 2010 Sep 29. Ludwig-Maximilians-University of Munich, Munich, Germany

Sun W et al: TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res. 2010 Feb 1;16(3):857-66. Epub 2010 Jan 26. Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, USA

Smith IM et al: Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One. 2009;4(3):e4961. Epub 2009 Mar 23. John Hopkins Medical Institutions, Baltimore, Maryland, USA

Völker HU et al: Overexpression of transketolase TKTL1 is associated with shorter survival in laryngeal squamous cell carcinomas. Eur Arch Otorhinolaryngol. 2007 Dec;264(12):1431-6. Epub 2007 Jul 18. University of Wuerzburg, Wuerzburg, Germany

Pneumology

Lung cancer:

Feyen O et al: EDIM-TKTL1 blood test: a noninvasive method to detect upregulated glucose metabolism in patients with malignancies. Future Oncol. 2012;8(10):1349-59. Rhönklinikum Bad Berka

Feyen O et al: EDIM blood test: a non-invasive method to detect patients with malignancies. Cell Symposia July 6-8, 2012: Poster 

Kayser G et al: Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology. 2011 Dec;43(7):719-24. University Hospital Freiburg, Freiburg, Germany

Kayser G et al: Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn Pathol. 2010 Apr 12;5:22. University Hospital Freiburg, Freiburg, Germany

Prasad V et al: Transketolase-like 1 (TKTL1), a new intracellular marker for staging of non-small cell lung cancer (NSCLC): Correlation with metabolic tumor size on F-18 FDG PET/CT. Poster SNM 2010. Central Clinic Bad Berka, Bad Berka, Germany

Smith IM et al: Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One. 2009;4(3):e4961. Epub 2009 Mar 23. Johns Hopkins Medical Institutions, Baltimore, Maryland, USA

Urology

Prostate cancer:

Grimm M et al: A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells. BMC Cancer. 2013, 13:569. University Hospital Tuebingen, DKFZ Heidelberg

Arnoldt J: Therapy monitoring and early detection of metastasis using tumor protein detection in macrophages. Anticancer Research ISSN 0250-7005: 2011 May:2012. Mecical practice for cancer therapy, Darmstadt, Germany

Urothelial cancer:

Langbein S et al: Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer. 2006 Feb 27;94(4):578-85. University Hospital Mannheim, Mannheim, Germany

Kidney cancer:

Wu HT et al: Anaplastic nephroblastomas express transketolase-like enzyme 1. J Clin Pathol. 2009 May;62(5):460-3. Epub 2009 Jan 12. University of Cape Town, Cape Town, South Africa

Langbein S et al: Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer. Int J Cancer. 2008 Jun 1;122(11):2422-8. University of Amsterdam, Amsterdam, The Netherlands