Influence of TKTL1 on tumor growth in a xenograft model

Control HTC116 and TKTL1 suppressed HTC116 cells were subcutaneously implanted into nude athymic mice. In the TKTL1 suppressed group, tumor size was around 6 mm in diameter whereas in the non suppressed group, tumor size was up to 20 mm in diameter.

The control tumors with no suppression of TKTL1 where much bigger and had more blood vessels on their surface than the TKTL1 suppressed tumor group.